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Pharmacognosy & Phytochemistry: Chemistry of natural products, tests,
isolation, purification & characterization and estimation of
phytopharmaceuticals belonging to the group of Alkaloids, Glycosides,
Terpenoids, Steroids, Bioflavanoids, Purines,lipids, proteins. Pharmacognosy of
crude drugs and herbal products. Standardization of raw materials. Modern
techniques used for evaluation.
Pharmaceutical Chemistry: Structure, nomenclature, classification,
synthesis, SAR and metabolism of the following category of drugs, which are
official in Indian Pharmacopoeia and British Pharmacopoeia. Introduction to drug
design. Stereochemistry of drug molecules. Hypnotics and Sedatives, Analgesics,
NSAIDS, Neuroleptics, Antidepressants, Anxiolytics, Anticonvulsants,
Antihistaminics, Local Anaesthetics, Cardio Vas- cular drugs - Antianginal
agents Vasodilators, Adrenergic & Cholinergic drugs, Cardiotonic agents,
Diuretics, Antijypertensive drugs, Hypoglycemic agents, Antilipedmic agents,
Coagulants, Anticoagulants, Antlplatelet agents. Chemotherapeutic agents -
Antibiotics, Antibacterials, Sulphadrugs. Antiproliozoal drugs, Antiviral,
Antituber- cular, Antimalarial, Anticancer, Antiamoebic drugs. Diagnostic
agents..
Pharmaceutics: Formulation, Development and Storage of different dosage
forms and new drug delivery systems. Biopharmaceutics and Pharmacokinetics and
their importance in Pharmaceutical calculations. Study of physical properties of
drugs: Particle size and shape, pKa, solubility, partition coefficient,
crystallinity, polymor- phism and hygroscopicity. Study of chemical properties
of drugs: Hydrolysis, oxidation, reduction, recimization, polymerization and
their influence on formulation and stability of drug products.
Pharmacology: General pharmacological principles including Toxicology.
Drug interaction and Pharmacology of drugs acting on Central nervous system,
Cardiovascular system, Autonomic nervous system, Gastro intestinal system and
Respiratory system. Pharmacology of Autocoids, chemotherapeutic agents including
anticancer drugs, Bioassays, Immuno Pharmacology. Drugs acting on the blood &
blood forming organs. Clinical Pharmacy Therapeutic Drug Monitoring Dosage
regimen in Renal and hepatitic impairment. Drug - Drug interactions and Drug
-food interactions, Adverse Drug reactions. Medication History, interview and
Patient counseling.
Pharmaceutical Analysis and quality assurance: Concepts of qualitative and
quantitative analysis, fundamentals of volumetric analysis, methods-of
expressing concentration, primary and secondary standards; concept of error,
precision, accuracy, specificity, sensitivity, detection limit, linearity and
range. Ruggedness, standards, standardization, calibration of analytical
equipments. Principles, instrumentation and applications of the fo llowin g:
Abso rp tio n spectroscop y (UV, vis ib le & I R ) .Flu o r ime tr y, Fla me p h
o to me tr y, Potentiometry.Conductometry and Plarography. Pharmacopoeial assays
and chromatography methods.Quality assurance and quality control methods,
concepts of GMP and GLP and forensic pharmacy.
Pharmaceutical Biotechnology: Isolation, classification and taxonomy of
microorganisms. Pure culture techniques, theory and practice of sterilization,
microbial growth phases and kinetics, microbial transformation of steroids.
Fermentation technology- batch and continuous fermentation. General
characteristics and manufacture of antibiotics, vaccines and harmones.
Application and scope of recombinant DNA technology in manufacture of biological
products such as insuline and human growth harmones. Biochemical role of
hormones, Vitamins, Enzymes, Nucleic acids, Metobolic path.ways-glycolosis and
TCA cycle and transport across cell membranes.
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